Barcelona, the country’s second-largest city, is a cosmopolitan urban center known for its throbbing youthful energy and stellar architecture. Barcelona is known for parks, nightlife, museums, shopping, and historic sites. Your plan includes some of its best attractions: admire the striking features of Basilica of the Sagrada Familia, don’t miss a visit to Casa Batllo, indulge your taste buds at Food & Drink, and shop like a local with La Boqueria.

A city of rich Moorish heritage, Seville is the cultural and financial center of southern Spain, and the site of numerous festivals throughout the year. Modern truly meets ancient here, and it’s not unusual to find the trendiest bars and swankiest nightclubs in the most medieval of settings. Narrow winding streets and hidden squares are lined with contemporary shops, award-winning restaurants, and innovative art galleries. Stunning architecture blends materials and elements from styles as varied as Gothic, Islamic, and Baroque. Flamenco and bullfighting traditions are still a big deal, but it’s the people, fun-loving and friendly, that may be the city’s biggest attraction.

Madrid is known for its cultural and artistic heritage, lively nightlife, and a dynamic culinary scene. Here are some ideas for day two: stroll around Parque del Retiro, then contemplate the long history of Plaza Mayor, and then see the interesting displays at Prado National Museum.